Vasculitis in Systemic Sclerosis

Systemic Sclerosis Presenting with Simultaneous Retinal Vasculitis in One Eye and Optic Neuritis in the other along with Severe Immune Haemolytic Anaemia Keywords: Systemic sclerosis, Retinal vasculitis, Optic neuritis, Autoimmune haemolytic anaemia

Systemic Sclerosis (SSc) is a connective tissue disorder which involves multiple systems in a chronic progressive manner. Micro–angiopathic haemolytic anaemia is a distinguished feature of “scleroderma renal crisis”, which is manifested by severe hypertension, a rapidly progressing renal dysfunction and hyperreninaemia and is seen in patients with an early, diffuse form of the disease. A nervou...

Ischemic Retinal Vasculitis and Its Management

Ischemic retinal vasculitis is an inflammation of retinal blood vessels associated with vascular occlusion and subsequent retinal hypoperfusion. It can cause visual loss secondary to macular ischemia, macular edema, and neovascularization leading to vitreous hemorrhage, fibrovascular proliferation, and tractional retinal detachment. Ischemic retinal vasculitis can be idiopathic or secondary to ...

Systemic Vasculitis During the Course of Systemic Sclerosis

Although the presence of antineutrophil cytoplasmic antibodies (ANCA) has been reported in patients with systemic sclerosis (SSc), the association of SSc and systemic vasculitis has rarely been described. We obtained information on cases of systemic vasculitis associated with SSc in France from the French Vasculitis Study Group and all members of the French Research Group on Systemic Sclerosis....

ANCA positive vasculitis in systemic sclerosis

Debilitating Bilateral Fibrosing Lumbar Plexopathy in a Patient with Systemic Sclerosis Sine Scleroderma

Systemic sclerosis is an autoimmune fibrotic disease which only rarely affects peripheral nerves. When it occurs, nerve damage is usually mediated by entrapment or small vessel vasculitis. Here we report the first case of bilateral lumbar fibrosing plexopathy in a patient with SSc sine scleroderma, an unusual form of SSc. Neurological symptoms were controlled with high dose prednisone and cyclo...

Systemic sclerosis-polymyositis overlap syndrome associated with autoimmune hepatitis and cerebral vasculitis.

Autoimmune hepatitis (AIH) is a chronic disorder characterized by persistent hepatocellular inflammation and necrosis. AIH overlap syndromes with other autoimmune diseases have been reported, including connective tissue diseases (CTD). Reports of AIH in systemic sclerosis (SSc), however, are scarce and have been particularly described in the limited SSc subtype. We report a case of systemic scl...